If you launch lots of programs, calculate alot (2+3 =5) and you hate to run with the mouse through Start>Programs>Accessories>Calc
Start>Programs>Mozilla>Firefox .. every time u need to start a program ..then
YOU must try Launchy (an opensource launcher for windows)
if you are a GNOME user .. then you probably know Gnome Do
Below are shown various shots of Launchy in action, opening a variety of files and programs – in just a few taps of the keyboard.